Table 2A.
Multivariate analysis for predictors of overall survival
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Gender (male) | 0.7 | 0.39–1.23 | 0.21 | |||
| Age (>68 years old)a | 1.43 | 0.81–2.53 | 0.21 | |||
| Histological type (undifferentiated) | 3.1 | 1.45–6.63 | 0.004 * | 2.16 | 0.94–4.95 | 0.07 |
| Location (left) | 0.68 | 0.38–1.22 | 0.2 | |||
| T classification (pT3/4) | 4.8 | 1.9–12.1 | 0.0009 * | 2.6 | 0.91–7.39 | 0.07 |
| Vessel involvement (present) | 2.42 | 1.35–4.33 | 0.003 * | 0.67 | 0.32–1.43 | 0.3 |
| Lymphatic vessel involvement (present) | 3.24 | 1.28–8.19 | 0.013 * | 1.08 | 0.36–3.22 | 0.89 |
| Lymph node metastasis (present) | 4.49 | 2.43–8.31 | <0.0001 * | 2.42 | 1.16–5.06 | 0.019 * |
| Distant metastasis (present) | 5.45 | 3.03–9.79 | <0.0001 * | 3.02 | 1.51–6.02 | 0.002 * |
| PMI (low)b | 7.39 | 3.67–14.9 | <0.0001 * | 4.69 | 2.19–10 | 0.0001 * |
| IMAC (high)b | 2.87 | 1.61–5.12 | 0.0003 * | 1.13 | 0.58–2.19 | 0.73 |
CI, confidence interval; HR, hazard ratio; IMAC, intramuscular adipose tissue content; PMI, psoas muscle mass index.
a
The median age at surgery in this cohort was 68 years.
b
Cut‐off thresholds of PMI/IMAC were determined by receiver operating characteristic analysis with Youden's index for overall survival in colorectal cancer patients.
*
P < 0.05. Bold font means significant p‐value in these tables.