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. 2019 Jun 24;7:e7165. doi: 10.7717/peerj.7165

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© 2019 Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Autophagosomes are indicated by black arrows, mitochondria are indicated by white arrows. Flameng score indicating mitochondrial damage, the higher the score, the more severe the mitochondrial damage. Mitochondria were swollen in the BNIP3 silencing group, and autophagosomes were significantly accumulated. (A) H/R+NC group (B) H/R+siBNIP3 group (C) H/R+SpostC+NC group (D) H/R+SpostC+siBNIP3 group (E) Autophagosome number per cell (F) FlaMeng Score. Data represent mean ± SD (n = 5/group) (^P < 0.05 vs H/R+siBNIP3 group, *P < 0.05 vs H/R+NC group, ^$P < 0.05 vs H/R+SpostC +NC group).