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. 2019 Jun 24;7:e7165. doi: 10.7717/peerj.7165

Figure 8. Expression of HIF-1α, BNIP3 and Beclin-1 protein in each group after silencing of BNIP3.

Figure 8

(A) Western blot images of each group; (B) HIF-1α protein expression; (C) BNIP3 protein expression; (D) Beclin-1 protein expression; BNIP3 is a downstream target protein of HIF-1 to demonstrate that HIF-1/BNIP3 is involved in SPostC to promote mitochondrial autophagy by silencing BNIP3. Protein expression in the BNIP3 silencing groups was significantly downregulated. HIF-1α expression was not affected. Data represent mean ± SD (n = 3/group) (^P < 0.05 vs H/R+siBNIP3 group, *P < 0.05 vs H/R+NC group, $P < 0.05 vs H/R+SpostC +NC group).