Table 2.
Model without intact PSA and hK2 |
Model including intact PSA and hK2 |
Difference | |
---|---|---|---|
Cohort | AUC (95% CI) | AUC (95% CI) | Increase in AUC (95% CI) |
Goteborg 1st Round | 0.749 (0.636, 0.861) | 0.900 (0.837, 0.964) | 0.151 (0.052, 0.251) |
Goteborg 2nd Round | 0.675 (0.590, 0.760) | 0.796 (0.730, 0.862) | 0.121 (0.054, 0.188) |
Rotterdam 1st Round | 0.807 (0.772, 0.842) | 0.859 (0.828, 0.889) | 0.052 (0.024, 0.079) |
Rotterdam 2-3rd Round | 0.744 (0.682, 0.805) | 0.797 (0.748, 0.847) | 0.053 (0.002, 0.105) |
Rotterdam Repeat Biopsy | 0.861 (0.759, 0.963) | 0.883 (0.803, 0.963) | 0.022 (−0.050, 0.094) |
Tarn | 0.763 (0.683, 0.844) | 0.857 (0.798, 0.916) | 0.093 (0.032, 0.155) |
ProtecT | 0.734 (0.713, 0.756) | 0.799 (0.781, 0.818) | 0.065 (0.047, 0.083) |
UPCA | 0.703 (0.652, 0.755) | 0.765 (0.718, 0.812) | 0.062 (0.022, 0.101) |
Opko | 0.717 (0.675, 0.760) | 0.805 (0.771, 0.840) | 0.088 (0.056, 0.120) |
Veterans Affairs | 0.659 (0.591, 0.726) | 0.751 (0.693, 0.810) | 0.092 (0.042, 0.142) |
Overall (fixed effects estimate) | 0.742 (0.727, 0.756) | 0.813 (0.801, 0.825) | 0.069 (0.057, 0.080) |
Overall (random effects estimate) | 0.739 (0.707, 0.770) | 0.818 (0.792, 0.844) | 0.071 (0.056, 0.085) |