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. 2019 Jun 20;13:657. doi: 10.3389/fnins.2019.00657

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Copyright © 2019 Filippi, Spinelli, Cividini and Agosta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional connectivity state results. (A) Group-specific cluster centroid for each state, averaged across subject-specific median cluster centroids of each group [percentage of total occurrences for stage I and II: 83.4% and 16.6% in the healthy controls (HC) and 70.8% and 29.2% in the Parkinson’s disease (PD) group, respectively]. (B) Functional connectivity in each state is shown for healthy controls and Parkinson’s disease groups, representing the 5% of the functional connectivity network with the strongest connections. BG, basal ganglia; AUD, auditory; SMN, sensorimotor; VIS, visual; CEN, cognitive executive; CB, cerebellar network (reproduced with permission from Kim et al., 2017).