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. 2017 May 10;37(19):4913–4927. doi: 10.1523/JNEUROSCI.0159-17.2017

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Copyright © 2017 the authors 0270-6474/17/374913-15$15.00/0

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Figure 8. — N-type VGCCs act exclusively through nanodomain signaling. A1, Representative examples of EPSCs recorded in control (black) and in the presence of AgTx + EGTA-AM (blue). A2, EPSC amplitude of tightly coupled P/Q-type VGCCs (open blue circles) compared with the EPSC amplitude generated by the total population of P/Q-type VGCCs (red square). B1, Example of EPSCs recorded in control condition (black) and following the application of CTx + EGTA-AM (red). B2, Graph showing the EPSC amplitude generated by tightly coupled N-type VGCCs (open red circles) compared with the EPSC amplitude evoked by all N-type VGCCs during trains of stimuli. C, Percentage of effect of toxins, EGTA-AM, and combined application of compounds on the 1st and 10th EPSCs generated in trains. Coapplication of CTx and EGTA-AM prevents the decrease in the percentage of effect of CTx during trains. Data represent mean ± SEM. **p < 0.01.