Figure 1.

Attenuated fever in mice with gene deletion of Cox-2 in brain endothelial cells. a, Temperature recordings from WT and Cox-2^ΔSlco1c1 mice immune challenged by intraperitoneal injection of LPS (120 μg/kg). The initial temperature peak is due to the handling stress in conjunction with the injection procedure. It is prostaglandin independent (Saha et al., 2005) and does not differ between genotypes. b, Bar graph showing mean fever 5 h after LPS injection in WT type and Cox-2^ΔSlco1c1 mice. *p < 0.05. In a and b: n = 15 for WT LPS; n = 11 for Cox-2^ΔSlco1c1 LPS; n = 9 for WT NaCl; and n = 6 for Cox-2^ΔSlco1c1 NaCl. Error bars = SEM.