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. 2017 May 10;37(19):5035–5044. doi: 10.1523/JNEUROSCI.3846-16.2017

Figure 2.

Figure 2.

PGE2 levels in brain and plasma and Cox-2 mRNA expression in the hypothalamus in WT mice and in mice with gene deletion of Cox-2 in brain endothelial cells. a, Immune stimulation with LPS (120 μg/kg, i.p.) increases the PGE2 concentration in the CSF to similar levels in both WT and Cox-2ΔSlco1c1 mice. b, The immune-induced Cox-2 mRNA induction in the hypothalamus is significantly attenuated in Cox-2ΔSlco1c1 mice. **p < 0.01. c, The immune-induced levels of PGE2 metabolites in plasma do not differ between WT and Cox-2ΔSlco1c1 mice. In all graphs: n = 15 for WT LPS; n = 10–11 for Cox-2ΔSlco1c1 LPS; n = 9–10 for WT NaCl; and n = 5–8 for Cox-2ΔSlco1c1 NaCl. Error bars = SEM.