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Relationship among body temperature and PGE2 in the CSF, Cox-2 mRNA in the hypothalamus, and PGE2 metabolites in plasma, respectively, following immune stimulation with LPS (120 μg/kg, i.p.). a, Weak relationship between body temperature and PGE2 in the CSF. b, Strong relationship between body temperature and Cox-2 mRNA in the hypothalamus. c, Moderately strong relationship between body temperature and PGE2 metabolites in plasma. *p < 0.05, ***p < 0.001.
