Table 3.

Steroid profiling in brain (left hemisphere) and plasma of young adult C57BL6 mice of both sexes

Steroid	Left hemisphere (ng/g)		Plasma (ng/ml)
	Males	Females	Males	Females
5β-DHP	0.09 ± 0.08	0.14 ± 0.08	0.02 ± 0.01	0.02 ± 0.01
3β5α-THP	0.36 ± 0.11	0.09 ± 0.04**	0.01 ± 0.003	0.02 ± 0.004
3α5β-THP	0.09 ± 0.03	0.12 ± 0.07	0.07 ± 0.02	0.33 ± 0.07*
3α5α20α-HHP	0.39 ± 0.15	0.68 ± 0.15	0.18 ± 0.10	0.32 ± 0.07
3β5α20α-HHP	0.03 ± 0.02	0.04 ± 0.02	0.01 ± 0.003	0.04 ± 0.01
3α5β20α-HHP	0.01 ± 0.003	0.07 ± 0.04	0.03 ± 0.02	0.06 ± 0.02
20α-DHPREG	0.13 ± 0.02	0.14 ± 0.03	0.01 ± 0.005	0.02 ± 0.01
DOC	0.02 ± 0.01	0.11 ± 0.03	0.28 ± 0.13	0.20 ± 0.07
5α-DHDOC	0.23 ± 0.04	0.06 ± 0.01**	0.20 ± 0.06	0.09 ± 0.03*
5β-DHDOC	0.01 ± 0.01	0.21 ± 0.08	0.02 ± 0.0002	0.21 ± 0.07
3α5α-THDOC	0.11 ± 0.03	0.02 ± 0.01*	0.11 ± 0.05	0.03 ± 0.01
3α5β-THDOC	0.01 ± 0.01	0.15 ± 0.06	0.01 ± 0.01	0.39 ± 0.17
Corticosterone	3.76 ± 1.00	1.40 ± 0.33	10.2 ± 4.71	21.5 ± 5.99*
Testosterone	1.21 ± 0.39	0.02 ± 0.01	2.16 ± 0.87	0.01 ± 0.003*
5α-DHT	0.19 ± 0.06	0.02 ± 0.01**	0.08 ± 0.02	0.01 ± 0.002
3α5α-THT	0.16 ± 0.05	ND	0.25 ± 0.06	ND
Estradiol	0.04 ± 0.01	0.02 ± 0.01	0.02 ± 0.01	0.03 ± 0.01

Results are presented as means ± SEM (n = 6–10 per group) and were analyzed by two-way ANOVA (tissue × sex) followed by Newman–Keuls multiple-comparisons tests.

**p < 0.01,

*p < 0.05 compared with males.

Abbreviations of steroids are as for Table 1. ND, Not detected.