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. 2017 Jun 21;37(25):6021–6030. doi: 10.1523/JNEUROSCI.2281-16.2017

Figure 2.

Figure 2.

Both stress paradigms induce depression-like behaviors in rodents. A, Experimental scheme. B, FS and RTS animals exhibited significantly reduced preference for 1% sucrose solution compared with naive animals in the sucrose preference test (n = 8–14, F(2,29) = 8.07, p < 0.01, one-way ANOVA with Bonferroni post hoc analysis; p < 0.05 compared with naive and FS animals; p < 0.01 compared with naive and RTS animals). C, The amount of time spent in the open arm in elevated plus maze was significantly decreased in RTS animals (F(2,29) = 5.44, p < 0.01). However, this was comparable in the naive and FS groups (p > 0.9). RTS animals entered the open arms less frequently than naive animals (F(2,29) = 7.05, p < 0.01). The FS group had a tendency for less open arms entries (p < 0.1). D, FS and RTS animals showed comparable immobility times on the first day of the FST (F(2,29) = 0.33, p > 0.7). However, both groups of stressed animals spent significantly prolonged immobility times on day 2 in the FST compared with naive animals (F(2,29) = 7.71, p < 0.01, one-way ANOVA; p < 0.01, Bonferroni post hoc analysis compared with naive and FS animals; p < 0.05 compared with naive and RTS animals). *p < 0.05. **p < 0.01.