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Development of the AMPA:NMDA balance ((GluA2 − GluN1)/(GluA2 + GluN1)) in human V1. A, Scatterplot of the AMPA:NMDA balance across the lifespan fit with a quadratic function (R2 = 0.406, p < 0.0001), which peaked at 10.7 years (95% CI, 4.8–23.7 years). B, Age-binned results for the AMPA:NMDA balance. Scatterplot, histogram, and significance levels plotted using the conventions described in Figure 1. ***p < 0.001.
