Blockade of C5aR1 signaling at E12.5–E14.5 results in microstructural changes in adult brains. Top row, Significance map of Jacobian warping projected onto T1-weighted template average. Middle row, Significance map of FA values projected onto template average. For both maps: blue/purple, vehicle>PMX53 (C5aR1-A) treatment; red/yellow, PMX53>vehicle. Color-coded p values are shown at the bottom. Bottom row, Anatomical areas are labeled. Mot., Motor cortex; Orb., orbital cortex; OB, olfactory bulb; SS, somatosensory cortex; Gust., gustatory cortex; Pir., piriformis; CP, caudate/putamen; NA, nucleus accumbens; P., pallidum; H., hypothalamus; Veh, vehicle.