Table 2.
MRI volume comparison of brain regions for C5aR1-antagonist or vehicle-treated mice
| Area | Vehicle treatment |
C5aR1-A treatment |
p value | ||||
|---|---|---|---|---|---|---|---|
| Volume (mm3) | SE | n | Volume (mm3) | SE | n | ||
| Amygdala | 10.24 | 0.1425 | 7 | 10.18 | 0.2929 | 9 | 0.8764 |
| Caudate/putamen | 23.25 | 0.4326 | 7 | 22.85 | 0.5933 | 9 | 0.6175 |
| Corpus callosum and external capsule | 8.213 | 0.102 | 7 | 7.891 | 0.331 | 9 | 0.4203 |
| Central gray matter | 4.476 | 0.05 | 7 | 4.339 | 0.07 | 9 | 0.1762 |
| Cerebellum | 46.96 | 0.3563 | 7 | 42.83 | 1.764 | 9 | 0.0624 |
| Fimbria | 2.007 | 0.028 | 7 | 1.928 | 0.05576 | 9 | 0.2702 |
| Globus pallidus | 2.485 | 0.055 | 7 | 2.368 | 0.046 | 9 | 0.1209 |
| Hippocampus | 24.71 | 0.287 | 7 | 24.31 | 0.5846 | 9 | 0.5832 |
| Hypothalamus | 11.61 | 0.162 | 7 | 11.17 | 0.284 | 9 | 0.234 |
| Neocortex | 125.5 | 1.84 | 7 | 121.5 | 3.45 | 9 | 0.3668 |
| Olfactory bulbs | 17.88 | 0.2216 | 6 | 16.53 | 0.7673 | 9 | 0.1858 |
| Thalamus | 25.19 | 0.095 | 7 | 24.69 | 0.732 | 8 | 0.5444 |