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. 2017 Oct 18;37(42):10240–10251. doi: 10.1523/JNEUROSCI.0031-17.2017

Figure 2.

Figure 2.

MACO-1 regulates forgetting of adaptation to diacetyl in the nervous system. A, Schematic depiction of the maco-1 gene and of lesions in maco-1 mutants. Arrows indicate locations of the two maco-1 alleles, and the solid bar indicates a deleted region of qj143. B, Retention of adaptation to diacetyl in maco-1 mutant animals. Chemotaxis of naive, adapted, and 4-h-recovered animals were analyzed (n = 6, 2-way ANOVA, Fstrain(3,60) = 8.3, p < 0.001). C–F, Transgenic rescue of maco-1 (qj143) mutant animals by expressing wild-type gene products under the following promoters: Primb-1, Pmyo-3, Podr-1, Podr-10, Prig-3, Pnmr-1, Punc-9, Pglr-4, Pacr-15, and Pasic-1 (Primb-1: n = 12, 2-way ANOVA, Fstrain(2,99) = 11.3, p < 0.001; Pmyo-3: n ≥ 6, 2-way ANOVA, Fstrain(2,117) = 316, p < 0.001; Podr-1: n = 8, 2-way ANOVA, Fstrain(2,63) = 16.3, p < 0.001; Podr-10: n = 6, 2-way ANOVA, Fstrain(2,45) = 36.1, p < 0.001; Prig-3: n = 8, 2-way ANOVA, Fstrain(2,63) = 14.2, p < 0.001; Pnmr-1: n = 10, 2-way ANOVA, Fstrain(2,81) = 5.2, p < 0.001; Punc-9: n = 8, 2-way ANOVA, Fstrain(2,63) = 7.9, p < 0.001; Pglr-4: n = 14, 2-way ANOVA, Fstrain(2,117) = 30.5, p < 0.001; Pacr-15: n = 14, 2-way ANOVA, Fstrain(2,117) = 10.1, p < 0.001; Pasic-1: n ≥ 4, 2-way ANOVA, Fstrain(2,75) = 28.2, p < 0.001). **p < 0.01; post hoc t test with Bonferroni's correction (B–F). Error bars represent SEM.