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. 2017 Apr 19;37(16):4231–4242. doi: 10.1523/JNEUROSCI.0756-16.2017

Figure 4.

Figure 4.

Cerebellum and BG cell morphology in Cox10 conditional mutant mice. A, Hematoxylin staining showing that the cerebellum appears normal in mutant mice (14 months). Scale bar, 500 μm. B, Single BG cells colabeled for S100β (red) and GFAP (green) were morphologically indistinguishable in 14-month-old mutant mice and controls. Asterisks mark PCs (unstained). Scale bar, 100 μm. C, Quantification of BG cell numbers at the age of 3 and 9–10 months. D, At the electron microscope level, mutant BG exhibit glycogen inclusion of normal size and mitochondria are morphologically unaffected (age 10 months). Scale bar, 500 nm. E, Quantitation of mitochondrial data. Numbers are mean ± SEM. G, Glycogen; N, nucleus; M, mitochondria; n.s., not significant.