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. 2017 Apr 12;37(15):4145–4157. doi: 10.1523/JNEUROSCI.3333-16.2017

Figure 6.

Figure 6.

Adult neurogenesis ablation in the vDG blocked the anxiolytic effect of EE-VEx in chronic inflammatory pain. A, B, Neurogenesis ablation in the dDG had limited effects on anxiety-like behaviors in open-field (A) and elevated plus-maze (B) tests 14 d after CFA injection. C, D, Adult neurogenesis ablation in the vDG abolished the anxiolytic effect of EE-VEx in chronic pain. n = 8 in each group. *p < 0.05, **p < 0.01, two-way ANOVA with Bonferroni's post hoc test. E, F, Adult neurogenesis ablation in the vDG but not in the dDG aggravated anxiety-like behaviors in mice under BH (28 d after CFA injection). n = 8 in each group. T.Dis and T.Entries remained similar in all groups. *p < 0.05, t test. G, H, Adult neurogenesis ablation in the vDG but not in the dDG increased defecation during habituation and testing phases of PWL measurement. Data were expressed as minimum–median–maximum. n = 9 in each group. **p < 0.01, Mann–Whitney U test.