Figure 8.

BDNF overexpression in the vDG but not in the dDG alleviated thermal hyperalgesia and reversed anxiety-like behaviors in chronic pain. A, B, BDNF overexpression in the dDG did not affect baseline thermal pain thresholds (A) or CFA-induced thermal hyperalgesia (B). n = 9 in each group. C, D, BDNF overexpression in the vDG did not affect baseline thermal pain thresholds (C) but attenuated CFA-induced chronic thermal hyperalgesia (D). n = 10 in each group. **p < 0.01, ANOVA with repeated measures and Bonferroni's post hoc test. E, F, AAV-BDNF expression in the vDG but not in the dDG reversed anxiety-like behaviors of mice with chronic pain, indicated by increased C.Time and C.Dis in the open field (E) and increased O.Time and O.Entries in the elevated plus-maze (F). n = 9 in dDG groups, n = 10 in vDG groups. *p < 0.05, **p < 0.01, t test.