Figure 9.
Adult neurogenesis in the dDG but not in the vDG contributed to the cognitive-improving effect of EE-VEx in chronic inflammatory pain. A, The object–place recognition task. One object (OB) was moved to a novel place in the test phase, and the bias score was calculated as exploring times (OB − OA)/(OB + OA) in sample and test phases. B, Impaired object–place recognition in mice with chronic inflammatory pain was reversed by EE-VEx. n = 8 in each group. *p < 0.05 vs saline group, #p < 0.05 vs CFA group, one-way ANOVA with Bonferroni's post hoc test. C, Ablating adult neurogenesis in the dDG but not in the vDG reversed EE-VEx's cognitive-enhancing effect. n = 8 in each group. *p < 0.05, t test. D, BDNF overexpression in the dDG improved object–place recognition of mice with chronic inflammatory pain. n = 8 in each group. *p < 0.05, t test.