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. 2017 Apr 12;37(15):4007–4022. doi: 10.1523/JNEUROSCI.4070-15.2017

Figure 6.

Figure 6.

GABA cells in the CeA promote cataplexy. A, B, Hypnograms displaying behavioral states of one orexin−/−,VGAT-Cre mouse during baseline (i.e., saline) conditions and activation of GABA CeA cells. C, During activation of GABA CeA cells (denoted as “hM3Dq”), a large increase in the total time spent in cataplexy was observed. This same increase was not apparent in a group of 6 hM3Dq-negative orexin−/−,VGAT-Cre mice (denoted as “mCherry”). D, This cataplexy change arose from an increase in the number of cataplexy episodes (per 3 h recording) that hM3Dq-expressing mice experienced. Mice lacking the hM3Dq receptor experienced similar numbers of cataplexy episodes after CNO injection. E, Average duration of cataplexy episodes did not change after CNO injection in hM3dq-positive and hM3Dq-negative mice. W, Wakefulness; SA, sleep attacks; CAT, cataplexy. ***p < 0.001; **p < 0.01.