Table 2.

Annotated upstream kinases potentially responsible for the altered phosphorylation levels upon GD1a treatment of OLGs

Condition	Kinases up	Peptides	Kinases down	Peptides
0 vs 10 min			Not known
0 vs 20 min	PKA	4	CDK2/CDK7	1
	PKG/cGK	2	GSK3, RSK, CAM-KII, CDK3, SGK, DYRK3	1
	P70S6K	2
	RSK group	2
	PKB group	2
	PKC-α	1
	PIM1	1
	CAM-KII	1
	AMPK	1
0 vs 16 h			PKB group	2
			ATM	1
			CDK2/CDK7	1
			PKA group	1
20 min vs 16 h	ATM	1	PKA group	2
	PKA group, PKG/cGK group	1	PKB group	3
	GSK3 group, RSK group, CDK3, CAM-KII group, CAM-KIV, DYRK3, MAPKAP2, SGK group	1	PKC group	1
			RSK group	1
			CDK2/CDK7	1
			PIM1	1
			Aurora A/B	1