Skip to main content
. 2017 Jul 5;37(27):6558–6574. doi: 10.1523/JNEUROSCI.0200-17.2017

Figure 9.

Figure 9.

Removal of all sialic acids in the NTS causes rapid sympathoexcitation and acute hypertension. A, Representative traces of integrated and smoothed neurogram of sSNA and arterial pressure following Neu (blue, 0.1 U/μl) or saline (control) microinjected into the NTS. Gray represents the period of injection. B, Grouped data show the time course of response in sSNA and MAP following Neu microinjection (n = 6). sSNA increased by 79.3% (p < 0.0001) and arterial pressure increased acutely (p = 0.0014), returning to baseline after 60 min (p = 0.157). Ci, Grouped data at 15 min after injection show that, compared with control, Neu significantly increased sSNA (158.5 ± 1.2 μV, p < 0.0001, n = 6) and MAP (152.8 ± 10.9 mmHg, p = 0.0014), whereas endoNF evoked a smaller increase in sSNA (119.3 ± 4.80%, p = 0.0039, n = 6) but did not change MAP (98.24 ± 9.12 mmHg, p = 0.977). Cii, Grouped data at 60 min after injection show that, compared with control, both Neu and endoNF increased sSNA (179.3 ± 14.56 and 140.80 ± 7.63 μV, p = 0.0004 and p = 0.0357, respectively) but had no significant effect on MAP (108.5 ± 3.12 and 95.02 ± 6.40 mmHg, p = 0.157 and p > 0.99, respectively). Data are mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, p > 0.05.