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. 2017 Oct 4;37(40):9741–9758. doi: 10.1523/JNEUROSCI.0681-17.2017

Figure 1.

Figure 1.

GSNOR expression increased in aging brain of human and mice. A, GSNOR gene expression over life span in human prefrontal cortex (n = 231 human from GSE30272 (Colantuoni et al., 2011); correlation analysis, p = 0.0008, r = 0.22). B, GSNOR gene expression over life span in human hippocampus (n = 26 human from GSE25219 (Kang et al., 2011; Pletikos et al., 2014); correlation analysis, p = 0.0091, r = 0.501). C, GSNOR mRNA level in adult (7-month-old) and old (22-month-old) mouse hippocampus (n = 6 mice; two-tailed Student's t test, p = 0.019). D, GSNOR protein expression in adult (7-month-old) and old (22-month-old) mouse hippocampus (adult mice, n = 4; old mice, n = 5; two-tailed Student's t test, p = 0.0008). Quantitation of GSNOR protein levels in right. Data are mean ± SEM. *p < 0.05, **p < 0.01.