Figure 10.

l-Arg rescued GSNOR TG mouse cognitive impairment in behavior tests. A, NO level is tested by the Griess method in mouse hippocampus. l-Arg (500 mg/kg) was intraperitoneally injected 30 min earlier (WT, n = 5; TG, n = 5). B, Number of arm entries that mice explored the Y-maze. l-Arg (500 mg/kg) was intraperitoneally injected 30 min earlier. C, Percentage alternations among Y-maze arms in exploration. l-Arg (500 mg/kg) was intraperitoneally injected 30 min earlier (WT, n = 20; TG, n = 23; one-way ANOVA, p = 0.038, TG vehicle vs WT vehicle, p = 0.047, TG vehicle vs TG l-Arg). D, Percentage time of mice spent freezing at exploration and 24 h after context training in a fear-conditioning task (TG, n = 13; WT, n = 14; two-tailed Student's t test, p = 0.034). E, The freezing time of every minute in the 24 h retention test was shown. l-Arg (500 mg/kg) was intraperitoneally injected 30 min earlier (TG, n = 13; WT, n = 14; one-way ANOVA, p = 0.0083, TG vs TG l-Arg, 5 min). Data are mean ± SEM. *p < 0.05. **p < 0.01.