Figure 11.

Summarized schematic model. GSNOR expression increased in aging mouse hippocampus. TG mice overexpressing GSNOR exclusively in neurons (GNSOR TG mice) had cognitive impairment, LTP impairment, and lower dendrite spine. GSNOR KO mice rescued age-related cognitive impairment. GSNOR induced cognitive impairment by downregulated S-nitrosated CaMKIIα, inhibited CaMKIIα synaptosomal accumulation, and downregulated p(S831)-GLUR1. Supplement of the NO signaling pathway rescued GSNOR TG mouse cognitive impairment.