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. 2017 Oct 4;37(40):9741–9758. doi: 10.1523/JNEUROSCI.0681-17.2017

Figure 6.

Figure 6.

GSNOR decreased CaMKIIα S-nitrosation modification in aging hippocampus. A, Detection of CaMKIIα S-nitrosation modification level in 7-month-old (adult) and 22-month-old (old) mouse hippocampus. B, Quantitation of SNO-CaMKIIα level in in 7-month-old (adult) and 22-month-old (old) mouse hippocampus (7-month-old, n = 5 mice; 22-month-old, n = 5 mice; two-tailed Student's t test, p = 0.0047). C, Detection of CaMKIIα S-nitrosation modification level in GSNOR TG mouse hippocampus. D, Quantitation of SNO-CaMKIIα level in GSNOR TG mice hippocampal (n = 6 experiments; two-tailed Student's t test, p = 0.0031). E, Detection of CaMKIIα S-nitrosation modification level in GSNOR KO aging mice (22-month-old) hippocampus. F, Quantitation of SNO-CaMKIIα level in GSNOR KO aging mice (22-month-old) hippocampus (WT, n = 4 mice; KO, n = 4 mice; two-tailed Student's t test, p = 0.0026). Data are mean ± SEM. **p < 0.01.