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. 2017 Oct 4;37(40):9741–9758. doi: 10.1523/JNEUROSCI.0681-17.2017

Figure 8.

Figure 8.

GSNOR decreased p(S831)-GLUR1 in aging hippocampus. A, p-GLUR1 (S831) level in adult (7 months) and old (22 months) mouse hippocampal synaptosomal fraction. Quantitation of p-S831 level normalized by synaptosomal marker SYP at right (adult, n = 3 mice; old, n = 3 mice; two-tailed Student's t test, p = 0.0043). B, p-GLUR1 (S831) level in primary hippocampal neuron synaptosomal fraction. Neuron was transfected by ctrl or GSNOR lentivirus plasmid. Quantitation of p-S831 level normalized by synaptosomal marker SYP at right (n = 3 experiments; two-tailed Student's t test, p = 0.0061). C, p-GLUR1 (S831) level in GSNOR KO aging mice (22 months) hippocampal synaptosomal fraction. Quantitation of p-S831 level normalized by synaptosomal marker SYP at right (WT, n = 4 mice; KO, n = 4 mice; two-tailed Student's t test, p = 0.033). Data are mean ± SEM. *p < 0.05, **p < 0.01.