Figure 3.

Tg(CJD) mice have proliferation of astrocytes and microglia in the hippocampus. A, Brain sections from Tg(CJD) mice at the ages indicated were stained with anti-GFAP antibody. Immunostaining revealed marked astrocytosis in the hippocampus. B, Immunostaining with anti-CD11b shows marked microgliosis in the hippocampus of a Tg(CJD) mouse at 60 d of age compared with an age-matched WT control. Scale bars, 100 μm. CA1, Field CA1 of hippocampus; h, hilus of the dentate gyrus. Insets, High-magnification images of resting (WT) and activated (CJD) microglia.