Figure 4.

Circadian rhythm is disturbed during epileptogenesis. A, B, Representative examples of smoothed theta relative power and locomotor activity signals in nonepileptic mice (A) or in mice undergoing epileptogenesis (B). C, D, Comparison of FFT analysis applied over the locomotor activity (C) and theta relative power (D) signals plotted in A and B between nonepileptic mice (N = 8) and mice undergoing epileptogenesis (N = 8). Comparison of the mean pick-to-pick theta relative power difference among nonepileptic animals (N = 8) and the difference between the start and end of epileptogenesis among animals undergoing epileptogenesis. E, Presented are the median values plus the range. *p = 0.0378.