Figure 11.

Specific Erbb4 deletion in the NAc core MSNs caused schizophrenia-like behavioral deficits. A, Hyperactivity of NAc-cKO mice in open-field test (n = 16). B, Fewer marbles were buried by NAc-cKO mice (n = 15). C, NAc-cKO mice showed normal interests in the first stranger compared with the controls in three chamber test (n = 14 NAc-Con and 13 NAc-cKO). D, NAc-Con and NAc-cKO mice showed comparable preference to the first stranger (n = 14 NAc-Con and 13 NAc-cKO). E, NAc-cKO mice spent similar time with the first stranger and the second stranger, indicating impaired social novelty recognition (n = 14 NAc-Con and 13 NAc-cKO). F, NAc-cKO mice had no preference to second stranger (n = 14 NAc-Con and 13 NAc-cKO). G, Decreased percentage of PPI in NAc-cKO mice (n = 15). In the behavior tests of the specific Erbb4 deletion in the NAc core, the virus expression of one NAc-cKO mouse was not limited to the NAc core, so its data were excluded for the behavior analysis. Statistical significance was determined by two-way ANOVA with Bonferroni post hoc test (A, C, E, G) or two-tailed t test for unpaired data (B, D, F). All data are shown as mean ± SEM. NS, No significant difference.