Figure 8.
Restored inhibitory transmission in the NAc core after α1 expression interference. A, Sample traces of mIPSC in the NAc core of cKO mice after GABAAR α1 expression interference in the same region. B–E, mIPSC frequency and amplitude were restored to normal levels in cKO-shRNA mice with histograms and cumulative distribution plots (n = 20 cells from 5 nonrescues and 22 cells from 4 rescues). In this experiment, all virus expression was restricted to the NAc core, so all the data were included in the mIPSC analysis. Statistical significance was calculated using K-S t test (B, D). All data are shown as mean ± SEM.