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Age at puberty onset in male and female AgRP-LepR KO mice compared with control animals. A, No significant difference in puberty onset was observed between male AgRP-LepR KO and control animals (n = 9). B, No significant difference in vaginal opening was observed between female AgRP-LepR KO and control animals, but a significant delay (p = 0.030) in age at first estrus was observed in the AgRP-LepR KO group (controls, n = 8; AgRP-LepR KO, n = 10). *p < 0.05.
