Figure 2.

SCIN ablation results in repetitive behaviors. No significant differences were observed in the accelerating rotarod (A) or during exploration of a novel open field (B). Self-grooming was normal but rearing events were increased (C, *p = 0.042, t test) during exposure to a small enclosure. D, Increased repetitive behavior was also observed in the hole-board exploration test (t test, *p = 0.037 and 0.048). E, Spontaneous alternation in the Y maze showed no deficit in short-term memory (t test, p = 0.13). Dotted line illustrates chance levels. F, Exacerbated marble-burying behavior exhibited by lesioned mice resembles repetitive behaviors present in OCD (*treatment factor p = 0.034). Left, Representative photographs at 6 min. G, No anxiety-like phenotype was observed for lesioned mice in the elevated plus maze test. The numbers of mice are indicated in figure references or inside columns.