Figure 3.
Striatal microinjection of DT produces similar effects than solvent in mice without the DT receptor. To rule out nonspecific effects of DT, a group of mice lacking the DTR (ChAT-Cre−/−; DTRloxP/loxP) were bilaterally microinjected in the striatum with the same dose of DT as used in previous experiments with ChAT-Cre+ mice (T, Toxin) or with saline (S, Solvent) as control. No significant differences were observed in exploratory activity in the open field (A, p = 0.98), marble-burying (B, p = 0.22, interaction p = 0.42), hole-board (C, p = 0.12), or social interaction (D, treatment factor p = 0.24, interaction p = 0.96) tests. Numbers of mice used are indicated inside columns or as graph labels in all panels.