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Description of the experimental animal groups, the viral vectors used, and the viral vector dose injected in the two overexpression experiments
| Virus | Low-dose RGMa overexpression |
High-dose RGMa overexpression |
|---|---|---|
| AAV2/7-RGMa, AAV2/7-Empty, AAV2/7-GFP, saline | AAV2/7-RGMa unilateral, AAV2/7-RGMa bilateral, AAV2/7-Empty | |
| Titer | 3.0 × 1012 | 9.0 × 1012 |
| No. of animals per group | N = 7–8, for saline N = 6 | N = 6 |
| Survival time (wk) | 12 | 18.5 |
