Table 1.
Participant characteristics and medical variables
| Patients (n = 26) | Healthy control (n = 26) | p value | |
|---|---|---|---|
| Sex (male) | 16 | 17 | 0.84 |
| Handedness (right) | 23 | 24 | 0.64 |
| Age at assessment, years | |||
| Mean | 12.67 | 12.01 | 0.54 |
| SD | 2.76 | 3.9 | |
| Range | 7.90–18.81 | 5.15–18.93 | |
| Age at diagnosis, years | |||
| Mean | 6.81 | — | — |
| SD | 2.34 | — | |
| Range | 2.58–11.59 | — | |
| Time from diagnosis to assessment, years | |||
| Mean | 5.86 | — | — |
| SD | 3.43 | — | |
| Range | 1.10–14.43 | — | |
| Tumor type | — | ||
| Anaplastic Astrocytoma | 1 | — | |
| Ependymoma | 4 | — | |
| Medulloblastoma | 21 | — | |
| Tumor location | |||
| Supra tentorial | 1 | — | — |
| Infratentorial | 25 | — | |
| No. of surgeries | — | ||
| 1 | 17 | — | |
| 2 | 4 | — | |
| 3 | 1 | — | |
| Radiation type | — | ||
| Focal (54–59.4 Gy) to tumor | 3 | — | |
| Focal (54–59.4 Gy) to tumor then cranial-spinal at recurrence (36 Gy) | 2 | ||
| Cranial-spinal (23.4–36 Gy) + boost (18–32.4 Gy) | 21 | — | |
| Treated with chemotherapy | 25 | — | — |
| Hydrocephalus | — | ||
| No hydrocephalus | 14 | — | |
| Hydrocephalus with no treatment | 4 | — | |
| Hydrocephalus requiring CSF diversion | 9 | — | |
| Scanner Type | |||
| GE LX 1.5T MRI | 14 | 11 | 0.41 |
| Siemens 3T | 12 | 15 | |
| Mean SNR GE LX 1.5T MRI | 12.52 | 9.88 | 0.52 |
| Mean SNR Siemens 3T | 33.70 | 29.19 | |
| DTI indices for OR | |||
| Mean fractional anisotropy | 0.41 | 0.43 | 0.000 |
| SD | 0.04 | 0.03 | |
| Mean diffusivity | 0.00083 | 0.00079 | 0.001 |
| SD | 0.00004 | 0.00003 | |
| Mean axial diffusivity | 0.00121 | 0.00119 | 0.110 |
| SD | 0.00005 | 0.00005 | |
| Mean radial diffusivity | 0.00064 | 0.00059 | 0.000 |
| SD | 0.00006 | 0.00005 |