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. 2017 Sep 13;37(37):8938–8951. doi: 10.1523/JNEUROSCI.0703-17.2017

Figure 2.

Figure 2.

Retrieval of cocaine cue memories induced increased calpain activity and decreased GRIP1 expression in the NAc core, but not shell. A, Experimental timeline. B, CPP scores in rats in the baseline and test phases. All six groups of rats acquired equivalent cocaine-induced CPP. *p < 0.05 compared with baseline test. C, SBDP and GRIP1 levels and representative Western blots in the NAc core after the retrieval of cocaine cue memories. SBDP increased significantly 30 min after the retrieval trial and then returned to baseline 1 h after the retrieval trial. The expression of GRIP1 decreased significantly 30 min after the retrieval trial and then returned to baseline 1 h after the retrieval trial. D, SBDP and GRIP1 levels and representative Western blots in the NAc shell after the retrieval of cocaine cue memories. No significant changes in SBDP or GRIP1 levels were observed after the retrieval trial. The data are expressed as a percentage (mean ± SEM) of SBDP and GRIP1 levels relative to naive rats (n = 8–9 per group). *p < 0.05 compared with the no retrieval (NoR) group. E, Experimental timeline. F, Expression of calpain protein in the NAc core. No significant changes in calpain protein levels were observed after the retrieval of cocaine cue memories. The data are expressed as a percentage (mean ± SEM) of calpain levels relative to naive rats (n = 6–7 per group).