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. 2017 Feb 1;37(5):1090–1101. doi: 10.1523/JNEUROSCI.2619-16.2016

Table 3.

Multiple regression resultsa

Water content
 Proton density
Adjusted R2 R2 change F p Adjusted R2 R2 change F p
Gray matter decreases in patients compared with control
    PCC R
        BPND 0.35 0.06 3.2 0.082 0.53 0.06 3.2 0.082
        T1/PD 0.20b 12.7b 0.001b 0.40b 35.5b <0.001b
        Group 0.12b 9.2b 0.004b 0.08b 8.3b 0.006b
        Group × BPND 0.04 2.8 0.102 0.04 3.9 0.055
        Group × T1/PD 0.00 0.1 0.730 0.00 0.0 0.961
    Fusiform R
        BPND 0.01 0.4 0.509 0.33 0.01 0.4 0.509
        T1/PD 0.01 0.6 0.452 0.04 2.1 0.158
        Group 0.31b 21.2b <0.001b 0.30 21.2b <0.001b
        Group × BPND 0.02 1.4 0.249 0.02 1.3 0.253
        Group × T1/PD 0.05 3.8 0.058 0.03 2.2 0.141
    Insula L
        BPND 0.31 0.11b 5.9b 0.018b 0.38 0.11b 5.9b 0.018b
        T1/PD 0.15b 9.8b 0.003b 0.23b 16.6b <0.001b
        Group 0.11b 8.1b 0.007b 0.08b 6.1b 0.017b
        Group × BPND 0.01 0.4 0.515 0.00 0.3 0.585
        Group × T1/PD 0.00 0.1 0.820 0.02 2.0 0.168
    Insula R
        BPND 0.34 0.06 3.4 0.072 0.42 0.06 3.4 0.072
        T1/PD 0.23b 15.3b <0.001b 0.29b 21.8b <0.001b
        Group 0.11b 8.9b 0.005b 0.10b 8.3b 0.006b
        Group × BPND 0.00 0.1 0.702 0.01 1.1 0.298
        Group × T1/PD 0.00 0.1 0.786 0.01 0.8 0.377
    MPFC R
        BPND 0.68 0.12b 6.6b 0.013b 0.77 0.12b 6.6b 0.013b
        T1/PD 0.55b 79.3b <0.001b 0.65b 131.1b <0.001b
        Group 0.04b 6.5b 0.014b 0.03b 6.2b 0.016b
        Group × BPND 0.01 1.0 0.326 0.00 0.3 0.578
        Group × T1/PD 0.00 0.3 0.594 0.00 0.9 0.347
    ACC L
        BPND 0.29 0.00 0.0 0.930 0.32 0.00 0.0 0.930
        T1/PD 0.13b 6.9b 0.012b 0.20b 11.8b 0.001b
        Group 0.21b 14.6b <0.001b 0.16b 11.9b 0.001b
        Group × BPND 0.02 1.6 0.206 0.03 1.9 0.180
        Group × T1/PD 0.00 0.0 0.861 0.00 0.2 0.695
    Precuneus R
        BPND 0.62 0.02 0.8 0.376 0.59 0.02 0.8 0.376
        T1/PD 0.42b 35.1b <0.001b 0.41b 34.0b <0.001b
        Group 0.15b 17.3b <0.001b 0.15b 16.8b <0.001b
        Group × BPND 0.06b 7.3b 0.010b 0.05b 5.8b 0.020b
        Group × T1/PD 0.02 2.0 0.168 0.01 0.7 0.398
    Precentral L
        BPND 0.38 0.00 0.0 0.925 0.40 0.00 0.0 0.925
        T1/PD 0.36b 27.3b <0.001b 0.40b 31.3b <0.001b
        Group 0.06b 4.8b 0.033b 0.04 3.7 0.061
        Group × BPND 0.02 1.4 0.249 0.02 1.4 0.246
        Group × T1/PD 0.00 0.2 0.650 0.00 0.0 0.828
    MTG L
        BPND 0.45 0.12b 6.5b 0.014b 0.45 0.12b 6.5b 0.014b
        T1/PD 0.34b 30.0b <0.001b 0.35b 31.0b <0.001b
        Group 0.03 2.6 0.116 0.03 2.8 0.098
        Group × BPND 0.01 0.5 0.471 0.01 0.5 0.505
        Group × T1/PD 0.01 0.9 0.354 0.01 0.6 0.431
Gray matter increases in patients compared with controls
    Angular gyrus L
        BPND 0.56 0.32b 22.7b <0.001b 0.61 0.32b 22.7b <0.001b
        T1/PD 0.22b 22.0b <0.001b 0.28b 34.0b <0.001b
        Group 0.06b 6.4b 0.015b 0.04b 4.6b 0.038b
        Group × BPND 0.00 0.0 0.899 0.01 0.6 0.439
        Group × T1/PD 0.01 1.5 0.225 0.01 0.6 0.430
    Cuneus R
        BPND 0.81 0.70b 114.0b <0.001b 0.87 0.70b 114.0b <0.001b
        T1/PD 0.12b 33.7b <0.001b 0.17b 65.6b <0.001b
        Group 0.00 1.0 0.324 0.00 1.1 0.298
        Group × BPND 0.00 0.9 0.358 0.01 2.0 0.160
        Group × T1/PD 0.00 0.1 0.794 0.00 0.1 0.795
    Postcentral gyrus R
        BPND 0.40 0.22b 13.6b 0.001b 0.47 0.22b 13.6b 0.001b
        T1/PD 0.18b 14.6b <0.001b 0.24b 20.7b <0.001b
        Group 0.05b 4.5b 0.039b 0.04 3.7 0.059
        Group × BPND 0.01 0.5 0.491 0.01 0.6 0.447
        Group × T1/PD 0.01 0.4 0.531 0.03 2.4 0.130

aGMV served as the dependent variable; flumazenil BPND, T1 time (water content) or proton density (PD), group (patients or controls), and the interaction terms served as the explanatory variables in the multiple regression analysis. L, Left; R, right.

bSignificant with cluster-level correction across the whole brain at p < 0.05.