Figure 7.

UCM03025 treatment enhances remyelination. Ultrastructural assessment of the myelin and axons by using electron microscopy at 105 dpi (A). UCM03025 treatment reduced the number of demyelinated axons in TMEV-infected mice and promoted remyelination (asterisks) in the ventral horn white matter of cervical spinal cords. Scale bars, 1 μm. Note the loss of myelin and unstructured myelin sheaths in TMEV (417 of 1000 axons) compared with sham and the increase in myelinated axons in UCM03025 (899 of 1000 axons) (B). ***p < 0.001 (χ² test). ^###p < 0.001 (χ² test). The g-ratios from the axons in UCM03025 were significantly higher than in sham and TMEV (C). Data are the mean ± SEM. ***p < 0.001 (Kruskal–Wallis one-way ANOVA, and pairwise multiple comparisons were done using the Dunn's method). ^###p < 0.001 (Kruskal–Wallis one-way ANOVA, and pairwise multiple comparisons were done using the Dunn's method).