Table 1.
The top pairwise similar characteristic direction expression responses for selected gene perturbations. Unless stated perturbations are relative to wild type/control conditions
| Perturbation | Accession | Species | Signed Jaccard |
|---|---|---|---|
| Eed knockout | GSE66862 | Mouse | |
| Ezh knockout | GSE84198 | Mouse | 0.0574 |
| Superficial versus deep zone cartilage | E-GEOD-54216 | Rat | 0.0563 |
| Dedifferentiating chondrocytes | GSE42235 | Human | 0.0447 |
| mOL-AR knockout | E-MTAB-1123 | Mouse | |
| AhsgHET versus Ahsg WT | GSE105139 | Mouse | 0.0579 |
| Hyp females versus Wildtype females | GSE5657 | Mouse | 0.0574 |
| Estrogen Receptor alpha knock-out | GSE41997 | Mouse | 0.0495 |
| DOT1L inhibition | GSE77916 | Human | |
| Galectin 1 treatment | E-GEOD-68760 | Human | 0.0400 |
| Galectin3 treatment | GSE85254 | Human | 0.0315 |
| IL-1 and glucosamine treatment | E-GEOD-6119 | Rat | 0.0311 |