Figure 9.

Viral restoration of GPR88 expression to the striatum restores reward density response discrimination in KO mice. A, WT mice injected with control virus (vWT, n = 7) and KO mice with GPR88 expression virally restored to the striatum (vrKO, n = 7) shifted responses to the high-reward (3 pellet) lever. KO mice that received control virus (vKO, n = 8) failed to acquire this choice profile. B, All groups completed similar training/no-choice trials (Block 1). C, vrKO mice completed more choice trials (Block 2) than control groups. D, KO groups (vKO, vrKO) consumed more pellets than WT controls (vWT) (cumulative, days 1–8). *p < 0.05, **p < 0.01 vs vWT.