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. 2019 Mar 29;10(3):696–709. doi: 10.1002/jcsm.12412

Figure 5.

Figure 5

Loss of 4E‐BP1 and 4E‐BP2 alters β‐oxidation in skeletal muscle. (A) Statistical heat map displaying the fold‐change values observed when short‐chain, medium‐chain, and long‐chain acylcarnitine abundance was compared between the quadriceps of 24‐month‐old WT and 4E‐BP1/2 DKO mice. The light pink indicates increases that trended towards significance with a 0.05 < P < 0.1. (B) Boxplots are shown for medium‐chain acylcarnitines and for the C2/carnitine ratio. (C) Real‐time PCR quantification of CPT1b and MCAD mRNA expression in quadriceps from WT and 4E‐BP1/2 DKO 24‐month‐old mice. (D) Respiratory quotient calculated as the ratio of VO2 to carbon dioxide production in WT and 4E‐BP1/2 DKO 24‐month‐old mice. *P < 0.05 vs. WT, **P < 0.01 vs. WT. n = 6 in each genotype.