Extended data Table 1.
Binding affinities of human STING mutants with TBK1
| Human STING (hSTING) | Human TBK1 1–657, S172A Kd (μM) |
M0US6 TBK1 1–657, S172A Kd (μM) |
M0US6 TBK1 1–657 Kd (μM) |
|---|---|---|---|
| hSTING 155–379 (no cGAMP) | ~230 | ~260 | |
| hSTING 55–379 | ~290 | ~170 | |
| p-hSTING 155–379 | 11.0 | 9.1 | 13.3 |
| p-hSTING 155.379 (no cGAMP) | 20.0 | 12.5 | |
| p-hSTING 155–341 | no binding | no binding | |
| p-hSTING 155–370 | no binding | no binding | |
| p-hSTING 342–379 | 16.8 | 15.3 | |
| p-hSTING 342–370 | no binding | no binding | |
| p-hSTING 353–379 | 22.6 | 25.1 | |
| p-hSTING 366–379 | 35.6 | 30.8 | |
| hSTING 366–379, F376W | ~190 | ||
| hSTING 155–379, T376E | ~62.0 | ||
| hSTING 356–379, T376E F378W | ~50.0 | ||
| hSTING 366–379, T376E F378W S379E | ~127 | ||
| hSTING 366–379, T376E F378W 3379M | 43.9 | ||
| hSTING 366–379, T376E F378W S379I | ~59.0 | ||
| hSTING 366–379, T376E F378W S379F | 27.1 | ||
| hSTING 356–379, T376E F376M S379W | 2.6 | 2.7 | |
| hSTING 155–379, T376E F378M S379VV | 1.4 | 1.2 |