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. 2017 Jan 25;37(4):1039–1054. doi: 10.1523/JNEUROSCI.1647-16.2016

Figure 6.

Figure 6.

Effects of VPA on T17M-transgenic retinas are reproduced by the HDACi's sodium butyrate (NaBu) and CI-994. A–C, Effects of NaBu on light exacerbated RD in T17M animals were essentially identical to the effects of VPA. Panels are as described in Figure 3, A–C (two-way ANOVA, cyclic light: pg = 3.7 × 10−15, pt = 1.6 × 10−9, pi = 4.2 × 10−6; two-way ANOVA, dark: pg = 0.002, pt = 0.29, pi = 0.77). n = 8–14 animals per group. D–F, Effects of CI-994 on light-exacerbated RD in T17M animals were essentially identical to the effects of VPA. Panels are as described in Figure 3, A–C (two-way ANOVA, cyclic light: pg = 6.1 × 10−11, pt = 5.2 × 10−8, pi = 2.6 × 10−5; two-way ANOVA, dark: pg = 0.156, pt = 0.013, pi = 0.538). n = 8–13 animals per group.