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. 2019 Jun 27;14(6):e0218410. doi: 10.1371/journal.pone.0218410

Table 3. Time trends in mortality rates by cause of death, before, during and after the 2008 economic crisis, in the Spanish men aged 15 to 64 years.

Annual Percentage Change (APC), 95% confidence interval (95% CI) and p value.

Causes of death (ICD-10 code1 2005–2007 (Before crisis) 2008–2010 (During crisis) 2011–2013 (During crisis) 2014–2016 (After crisis)
APC (95% CI) p value APC p value APC p value APC p value
All causes -2.8 (-3.4, -2.2) < 0.001 -4.1 (-4.4, -3.8) < 0.001 -3.0 (-3.4, -2.7) < 0.001 -1.5 (-1.9, -1.2) < 0.001
Cancer (C00-C97) -1.7 (-2.7, -0.8) < 0.001 -2.4 (-3.0, -1.8) < 0.001 -2.2 (-2.8, -1.7) < 0.001 -2.7 (-3.3, -2.1) < 0.001
Cardiovascular diseases (I00-I99) -2.7 (-4.0, -1.4) < 0.001 -5.4 (-6.2, -4.6) < 0.001 -2.5 (-3.3, -1.6) < 0.001 0.1 (-0.9, 1.0) 0.881
Digestive disease (K00-K93) -1.1 (-3.3, -1.2) 0.354 -4.4 (-5.7, -3.1) < 0.001 -3.4 (-4.7, -2.2) < 0.001 -2.8 (-4.3, -1.4) < 0.001
Respiratory disease (J00-J99) -0.5 (-3.1, 2.2) 0.712 -6.6 (-8.1, -5.0) < 0.001 -3.5 (-5.2, -1.9) < 0.001 2.5 (0.7, 4.4) 0.008
Infectious disease (A00-B99) -6.4 (-9.2, -3.5) < 0.001 -9.8 (-11.6, -8.0) < 0.001 -5.7 (-7.7, -3.7) < 0.001 -7.7 (-10.0, -5.3) < 0.001
Motor vehicle accidents2 -9.6 (-11.8, -7.3) < 0.001 -18.0 (-19.5, -16.5) < 0.001 -8.2 (-10.1, -6,3) < 0.001 1.8 (-0.7, 4.3) 0.167
Suicide (X60-X84+Y87.0) -1.5 (-4.5, 1.5) 0.324 -1.7 (-3.5, 0.2) 0.083 5.6 (3.7, 7.4) < 0.001 -3.3 (-5.1, -1.5) < 0.001

1. ICD-10: International Classification of Diseases, 10th revision

2. Motor vehicle accidents: V02-V04+V09.0+V09.2+V12-V14+V19.0-V19.2+V19.4-V19.6+V20-V79+V80.3-V80.5+V81.0-V81.1+V82.0-V82.1+ V83-V86+V87.0-V87.8+V88.8-V88.9+V89.0-V89.2