Trial	Intervention(s) and comparator(s)	Duration of intervention	Population	Study period (year to year)	Country	Setting	Ethnic groups (%)	Duration of diabetes (mean years (SD), or as reported)
Ferguson 2001	I: lispro	24 weeks	People with type 1 diabetes and impaired awareness of hypoglycaemia	‐	Scotland	Outpatient clinic of the Department of Diabetes, Royal Infirmary of Edinburgh	‐	26 (10)/10‐45
	C: RHI
Home 2000	I: aspart	6 months	Adults with type 1 diabetes	1997	Austria, Denmark, Finland, Germany, Norway, Sweden, Switzerland, UK	Multicentre, outpatients	White: 99	15 (10)
	C: RHI						White: 99	15 (10)
Iwamoto 2001	I: aspart	168 days	People with type 1 diabetes	‐	Japan	Hospital outpatients; physicians' clinics	Asian: 100	11 (7)
	C: RHI						Asian: 100	11 (6)
Provenzano 2001	I: lispro	6 monthsa	People with type 1 diabetes	‐	Italy	‐	‐	12 (3‐20)b
	C: RHI
Raskin 2000	I: aspart	6 months	People with type 1 diabetes	1997	US, Canada	Multicentre, outpatients	White: 94	16 (10)
	C: RHI						White: 93	16 (9)
Recasens 2003	I: lispro	12 months	People newly diagnosed with type 1 diabetes	‐	Spain	‐	‐	8.1 (3.8) weeks from diagnosis
	C: RHI							8.1 (8.0) weeks from diagnosis
Z011 2007	I: lispro	12 months	People with type 1 diabetes	1992‐1993	North America, Europe, South Africa	Multicentre, outpatients	‐	12
	C: RHI						‐	13
Z013 2007	I: lispro	12 months	People with type 1 diabetes	1992‐1993	North America, Europe, South Africa, Australia	Multicentre, outpatients	‐	13
	C: RHI						‐	11
Z015 2007	I: lispro	12 months	People with type 1 diabetes who had been on insulin therapy for < 2 months	1993‐1994	North America, Europe	Multicentre, outpatients	‐	0.2
	C: RHI						‐	0.2
aCross‐over study with total duration of one year, insulin was changed after six months (the six‐month long blocks were divided into two x three‐month blocks with normal and Mediterranean diet) b"12 (3‐2)" in the publication. We assume this might be a typing mistake and should be 12 (3‐20). "‐" denotes not reported C: comparator; I: intervention; RHI: regular human insulin; SD: standard deviation