Table 4. Logistic regression modeling of factors independently associated with leukoaraiosis.

	Univariate logistic regression			Multivariate logistic regression
	ORa	95%CI	P-value	ORa	95%CI	P-value
Age	1.124	1.075–1.175	<0.0001	1.167	1.040–1.309	0.0088*
Telomere length shortening	1.136	1.053–1.225	0.0009	1.23	1.03–1.45	0.023**
Hypertension	3.259	1.369–7.761	0.0076	1.285	0.189–8.719	0.7976
carotid artery plaquec	9.333	1.122–77.633	0.0388	9.175	0.63–133.5	0.1047

^a Odds ratios were calculated using univariate and multivariable logistic regression models.

^b older age, LTL shortening, hypertension, and carotid artery plaque were adjusted for in multiple logistic regression analysis.

^c Carotid artery plaque defined as carotid intima-media thickness (IMT) >1 mm, analyzed as a categorical variable.

*indicates p values <0.01,

**indicates p values<0.05