Figure 6. Ameliorated joint inflammation in Fra-1^ΔLysM arthritic mice.

K/BxN arthritis was induced in Fra-1^ΔLysM and control littermate mice. (A) Arthritis score of control, control^ΔLysM, and Fra-1^ΔLysM mice and quantification of AUC. (B) Quantification of soft tissue volume and representative images ascertained by MRI analysis of healthy control and arthritic control and Fra-1^ΔLysM mice. (C) Quantification of the inflammatory area, erosion area, and number of osteoclasts and representative images ascertained from H&E (top) and TRAP (bottom) staining of arthritic paws. The arrows indicate cell infiltrated areas in H&E staining and osteoclasts in TRAP staining, respectively. Scale bars: 500 μm. Graph points indicate individual mice. Data are shown as mean values, and error bars represent SEM. *P < 0.05; **P < 0.01; ***P < 0.001, Student’s t test (B and C) or ANOVA (A).