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. 2019 May 28;129(7):2669–2684. doi: 10.1172/JCI96832

Figure 9. Therapeutic l-arg supplementation resolves arthritis.

Figure 9

Arthritis was induced by K/BxN serum transfer to WT mice, supplemented with 40 g/l ʟ-arg in the drinking water, either simultaneously with the K/BxN serum transfer (d0) or therapeutically at d4 after serum transfer. Mice were analyzed at day 10 after serum transfer. (A) Arg1 activity in total paw lysates. (B) Arthritis score and its quantification of AUC. (C) Quantification of the inflammatory area, erosion area, and number of osteoclasts from the histological analysis of H&E (top) and TRAP (bottom) staining and its representative images. Scale bars: 500 μm. The arrows indicate cell infiltrated areas in H&E staining and osteoclasts in TRAP staining, respectively. Graph points indicate individual mice. Data are shown as mean values, and error bars represent SEM. *P < 0.05; **P < 0.01; ***P < 0.001, ANOVA.