Skip to main content
. 2019 Jun 10;129(7):2685–2701. doi: 10.1172/JCI127080

Figure 5. TKI treatment leads to enhanced inhibition of CML hematopoiesis in SIRT1-deleted mice.

Figure 5

SIRT1-deleted or control CML mice were treated with NIL or vehicle control for a period of 4 weeks, starting 10 weeks after SIRT1 deletion and CML induction (n = 7 per arm). (A–E) Effects of NIL treatment on spleen size (A), spleen weight (B), spleen cellularity (C), BM cellularity (D), and frequency of Gr1+Mac1+ myeloid cells in BM (E). (F–J) Effect of NIL treatment on absolute numbers of splenic LTHSCs (F), STHSCs (G), MPPs (H), GMPs (I), and MEPs (J). (K–O) Effect of NIL treatment on absolute numbers of BM LTHSCs (K), STHSCs (L), MPPs (M), GMPs (N), and MEPs (O). Error bars represent mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001, ordinary 1-way ANOVA, correcting for multiple comparisons by controlling the FDR using the 2-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli.